Highland Reel and Ryan Moore won the King George VI & Queen Elizabeth Stakes sponsored by QIPCO at Ascot.
After jumping out well, Moore kept Highland Reel at the front of a generous gallop and quickly found himself four lengths ahead.
Wings of Desire and Frankie Dettori attempted to narrow the gap, with Moore giving Highland Reel a rest rounding the final bend.
That jockeyship paid dividends as the Aidan O’Brien four-year-old found enough to hold Wings of Desire in the final furlong.
The Queen’s horse Dartmouth had too much to do in the closing stages but stayed on well for third.
Highland Reel’s stablemate Sir Isaac Newton finished fourth.
Trainer Aidan O'Brien said: "He’s a horse that can go anywhere from a mile and a quarter to a mile and a half - The Breeders Cup Turf, he can go to Australia, he can go to Hong Kong, Japan, he’s got an awful lot of options this horse.
“We knew he didn’t mind making the running, he’s very happy to make the running if nobody else wants to go. He won the Secretariat and killed them making the running so if he’s left in front, he’s very happy with that and if there’s pace he’s happy with that too - he’s a very unique horse really
“Ryan face him a great ride, you would be delighted really.”